Peroxynitrite oxidises catechols to o -quinones
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چکیده
منابع مشابه
Enzymatic O-methylation of epinephrine and other catechols.
Many studies in vitro have implicated cytochrome oxidase and monoamine oxidase in the metabolism of epinephrine and other cateehol amines (2). However, no evidence for the participation of cytochrome oxidase in the metabolism of epinephrine in viva has been obtained. Furthermore, several investigations have indicated that monoamine oxidase plays only a minor role in the inactivation of epinephr...
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Fully substituted quinones including some naturally occurring oxyquinones acted as inhibitors o f yeast gluta thione reductase (EC 1.6.4.2). They were competitive, mixed or uncompetitive inhibitors for N A D PH , possess ing K j in the range o f 1 2 0 0 |iM and uncompetitive in hibitors for glutathione. Rhein (4,5-dioxy-9,10-anthraquinone-2-carbonic acid) and 9,10-phenanthrenequinone were th...
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Raloxifene was approved in 1997 by the FDA for the treatment of osteoporosis in postmenopausal women, and it is currently in clinical trials for the chemoprevention of breast cancer. Before widespread use as a chemopreventive agent in healthy women, the potential cytotoxic mechanisms of raloxifene should be investigated. In the current study, raloxifene was incubated with GSH and either rat or ...
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Either chemical or enzymatic oxidation of catechols or catecholamines in the presence of nucleophiles (amino acids, peptides, and proteins) leads to the production of ring-substituted o-semiquinones which have been detected by ESR spin stabilization techniques. In many cases, radicals have been completely characterized and structures assigned. Chemical considerations point to a mechanism involv...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1998
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)01223-x